Methodology for the Serum Bactericidal Test; Approved Guideline<\/p>\n","protected":false},"excerpt":{"rendered":"
Bactericidal testing methods occasionally are used because of the awareness of the need for lethal antimicrobial activity to treat certain deep-seated infections, e.g., bacterial endocarditis. There also is an increased awareness of the need to consider the pharmacodynamic and pharmacokinetic principles of antimicrobial therapy. This often can be achieved by assessing both results of standardized susceptibility testing and of antimicrobial assays. The serum bactericidal test represents an alternative in vitro test that incorporates pharmacodynamic and pharmacokinetic principles. The test takes into consideration the susceptibility of the pathogen; measures the combined effect of absorption and elimination of the antibiotic; the binding of the drug to serum proteins; and the effect of the parent compound as well as any metabolites against the infecting organism. This assay also measures the effect of drug interactions. This includes both the synergistic or antagonistic effects of antibiotic combinations and the interactions of other drugs with antibiotics. Finally, the serum bactericidal test, by measuring the magnitude of antibiotic concentration relative to the MBC, allows a prediction of the aggregate time of bactericidal activity. <\/p>\n","protected":false},"featured_media":1817,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_cat":[26],"product_tag":[],"yoast_head":"\n